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1996 3
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2003 7
2004 6
2005 6
2006 3
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Page 1
Werner syndrome: entering the helicase era.
Epstein CJ, Motulsky AG. Epstein CJ, et al. Bioessays. 1996 Dec;18(12):1025-7. doi: 10.1002/bies.950181214. Bioessays. 1996. PMID: 8976161 Review.
Werner syndrome is a rare autosomal recessive disorder that mimics some of the characteristics of aging. ...These include altered nucleotide excision repair and RNA polymerase II-mediated transcription. The discovery of the helicase defect in Werner syndro …
Werner syndrome is a rare autosomal recessive disorder that mimics some of the characteristics of aging. ...These include alte …
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
Siitonen HA, Kopra O, Kääriäinen H, Haravuori H, Winter RM, Säämänen AM, Peltonen L, Kestilä M. Siitonen HA, et al. Hum Mol Genet. 2003 Nov 1;12(21):2837-44. doi: 10.1093/hmg/ddg306. Epub 2003 Sep 2. Hum Mol Genet. 2003. PMID: 12952869
The RECQL4 helicase gene is a member of the RECQL gene family, mutated in some Rothmund-Thomson syndrome (RTS) patients. Other members of this gene family are BLM mutated in Bloom syndrome, WRN mutated in Werner syndrome and RECQL and REC …
The RECQL4 helicase gene is a member of the RECQL gene family, mutated in some Rothmund-Thomson syndrome (RTS) patients. Other …
Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-kappaB signaling in cancer.
Gupta P, Majumdar AG, Patro BS. Gupta P, et al. Aging Cell. 2022 Jun;21(6):e13625. doi: 10.1111/acel.13625. Epub 2022 May 18. Aging Cell. 2022. PMID: 35582959 Free PMC article.
Mutation in Werner (WRN) RECQL helicase is associated with premature aging syndrome (Werner syndrome, WS) and predisposition to multiple cancers. In patients with solid cancers, deficiency of the WRN RECQL helicase is paradoxically associ …
Mutation in Werner (WRN) RECQL helicase is associated with premature aging syndrome (Werner syndrome, WS) …
RecQ helicases and PARP1 team up in maintaining genome integrity.
Veith S, Mangerich A. Veith S, et al. Ageing Res Rev. 2015 Sep;23(Pt A):12-28. doi: 10.1016/j.arr.2014.12.006. Epub 2014 Dec 30. Ageing Res Rev. 2015. PMID: 25555679 Review.
This is in accordance with clinical and epidemiological findings demonstrating that defects in three RecQL helicases, i.e., WRN, BLM, RECQL4, are related to human progeroid and cancer predisposition syndromes, i.e., Werner, Bloom, and Rothmund Thomson syndrome …
This is in accordance with clinical and epidemiological findings demonstrating that defects in three RecQL helicases, i.e., WRN, BLM, …
Pathways and functions of the Werner syndrome protein.
Lee JW, Harrigan J, Opresko PL, Bohr VA. Lee JW, et al. Mech Ageing Dev. 2005 Jan;126(1):79-86. doi: 10.1016/j.mad.2004.09.011. Mech Ageing Dev. 2005. PMID: 15610765 Review.
Mutations in human WRN (also known as RECQ3) gene give rise to a rare autosomal recessive genetic disorder, Werner syndrome (WS). WS is a premature aging disease characterized by predisposition to cancer and early onset of symptoms related to normal aging including …
Mutations in human WRN (also known as RECQ3) gene give rise to a rare autosomal recessive genetic disorder, Werner syndrome (W …
Unwinding the molecular basis of the Werner syndrome.
Shen J, Loeb LA. Shen J, et al. Mech Ageing Dev. 2001 Jul 15;122(9):921-44. doi: 10.1016/s0047-6374(01)00248-2. Mech Ageing Dev. 2001. PMID: 11348659 Review.
Werner syndrome (WS) is an autosomal recessive disease manifested by the premature onset of age-related phenotypes, including diseases such as atherosclerosis and cancer. ...
Werner syndrome (WS) is an autosomal recessive disease manifested by the premature onset of age-related phenotypes, including …
Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.
Fu W, Ligabue A, Rogers KJ, Akey JM, Monnat RJ Jr. Fu W, et al. Hum Mutat. 2017 Feb;38(2):193-203. doi: 10.1002/humu.23148. Epub 2016 Dec 9. Hum Mutat. 2017. PMID: 27859906 Free PMC article.
Heritable loss of function mutations in the human RECQ helicase genes BLM, WRN, and RECQL4 cause Bloom, Werner, and Rothmund-Thomson syndromes, cancer predispositions with additional developmental or progeroid features. ...The use of biochemical and model organism data, to …
Heritable loss of function mutations in the human RECQ helicase genes BLM, WRN, and RECQL4 cause Bloom, Werner, and Rothmund-Thomson …
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
Shen JC, Loeb LA. Shen JC, et al. Trends Genet. 2000 May;16(5):213-20. doi: 10.1016/s0168-9525(99)01970-8. Trends Genet. 2000. PMID: 10782115 Review.
Werner syndrome (WS) is an autosomal recessive genetic disorder that is manifested by genetic instability and premature onset of age-related diseases, including atherosclerosis and cancer. ...
Werner syndrome (WS) is an autosomal recessive genetic disorder that is manifested by genetic instability and premature onset …
Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique.
Lowe J, Sheerin A, Jennert-Burston K, Burton D, Ostler EL, Bird J, Green MH, Faragher RG. Lowe J, et al. Ann N Y Acad Sci. 2004 Jun;1019:256-9. doi: 10.1196/annals.1297.042. Ann N Y Acad Sci. 2004. PMID: 15247024 Review.
Werner syndrome (WS) is an inherited genetic disease in which individuals display the premature aging of a selected subset of tissues. ...
Werner syndrome (WS) is an inherited genetic disease in which individuals display the premature aging of a selected subset of …
Premature aging in RecQ helicase-deficient human syndromes.
Mohaghegh P, Hickson ID. Mohaghegh P, et al. Int J Biochem Cell Biol. 2002 Nov;34(11):1496-501. doi: 10.1016/s1357-2725(02)00039-0. Int J Biochem Cell Biol. 2002. PMID: 12200042 Review.
Werner's syndrome is a premature aging disorder with a complex phenotype, which includes many age-related disorders that develop from puberty, including greying and thinning of the hair, bilateral cataract formation, type II diabetes mellitus, osteoporosis and ather …
Werner's syndrome is a premature aging disorder with a complex phenotype, which includes many age-related disorders that devel …
58 results